Coulson finds himself back in the role of agent and teams with Mack to track down and confirm the presence of Inhumans. Agent May is tasked with training specialist strike teams, and Fitz and Simmons take a big step forward in their relationship.
As Coulson, Mack, and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness.
As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need. Meanwhile, Daisy reunites with a familiar face to stop the Watchdogs.
ABC's "Marvel's Agents of S.H.I.E.L.D." returns with a vengeance for the fourth exciting season, Robbie Reyes (Gabriel Luna) will roar into the lives of Agent Coulson and the team as a junkyard mechanic who can turn on a dime into the terrifying Ghost Rider. Will Robbie be a friend or foe to S.H.I.E.L.D. – as well as the world, itself? Meanwhile, Fitz discovers that socially awkward genius and friend Dr. Radcliffe (John Hannah) has started putting the finishing touches on a new, secret invention.